The first lady will speak during a luncheon hosted by Mayor Rahm Emanuel.
The Black Women's Expo, to be held this weekend, will honor Cleopatra Cowley-Pendleton, among others.
Nathaniel Pendleton Jr. was among the president's guests at the annual White House Easter Egg Roll.
Rapper attended Project Orange Tree rally Monday to combat violence in wake of Hadiya Pendleton's death.
Last month, there were 16 murders in Chicago, 36 fewer than in March of 2012, police said.
Two men pled not guilty in the murder while the girl's mother appeared with Obama at the White House.
The effort named for the slain Chicago teen aims to provide social, economic and educational services.
The Chicago rapper's "Jonylah Forever" is dedicated to the slain 6-month-old.
Measure would toughen penalty on 'straw purchasers' who re-sell guns to criminals.
Michael Ward and Kenneth Williams have been indicted in the 15-year-old South Sider's fatal shooting.
At a signing ceremony for another bill, Obama says families of violence "really do deserve a vote."
Retired Army General Russel Honore is credited for bringing calm to post-hurricane New Orleans.
Cleopatra Cowley-Pendleton calls for background checks in the PSA made by Mayors Against Illegal Guns.
President Barack Obama met privately with a small group of high school students before Friday's speech.
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