Protesters blocked traffic with banners reading "Eric Garner," "#ThisStopsToday" and "Mike Brown."
Dozens of streets across the city will be closed to traffic on Wednesday and Thursday.
The group WEPS wants to block southbound access to West End Avenue to curb illegal use by trucks.
The garage was shuttered Wednesday, but warnings had come as early as September 2013.
The Freeman Plaza parks are surrounded by four lanes of honking traffic entering the Holland Tunnel.
A crash involving two cars and a Jitney bus shut down a Manhattan-bound tube of the tunnel.
A controversy over a local Redskins team and the death of a homeless man's dog made news in New York.
The intersection of Riverside Drive and 157th Street has seen five accidents since July 2012.
The plan is part of an effort to redesign West End Avenue in light of two recent fatalities there.
Residents are concerned about how the closure will affect parking.
The city is preparing to unveil new safety plans Thursday for the residential corridor.
The DOT's plan would force drivers who want to go east on Myrtle Avenue to go west and make a u-turn.
Helen Rosenthal wants to extend "Cooper's Law" to cover all New York drivers.
The plan for 155th Street, Edgecombe Avenue and St. Nicholas Place has been in the works for years.
The shoot closed off Monroe Street between Franklin and Bedford avenues, causing congestion.
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