Service will be suspended between Queensboro Plaza and Times Square-42nd Street for five weekends.
A northbound 1 train struck a man in TriBeCa's Franklin Street station, police said.
Disruptions on the 1, 2, 3, 4, 5, 6, 7, C, D, E, F, G, M, N, Q, R and S begin late Friday.
Subway repair work will knock out A train service to most of Washington Heights and Inwood next week.
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