Drivers will have to slow to 25 mph on Broadway from Columbus Circle to 220th Street.
Residents are concerned about how the closure will affect parking.
The crosswalks will be at 48th and 49th Avenue near P.S./I.S. 78, where stop signs were recently added.
Residents of Lincoln Road in Prospect-Lefferts Gardens said the change occurred with no notice.
Investigators are looking to talk to construction workers and people involved in the July 4 fireworks.
The DOT will not immediately expand a slow zone to Sixth Avenue, despite requests from the community.
Milk Bar and three other local businesses have asked the DOT for bike corrals, the department said.
The change comes after calls from local leaders for traffic improvements on the Hunters Point street.
Elisa Toro, of The Bronx, was killed in December in a crash on the bridge's exit ramp.
The intersection of East 177th St. and Devoe Ave. will get improved passage to the Bronx River Greenway.
Locals say traffic safety improvements are needed on Center Boulevard.
Politicians lauded the new service, but advocates for the disabled said more could be done to help them.
The plan for 155th Street, Edgecombe Avenue and St. Nicholas Place has been in the works for years.
The plan would extend the median separating Astoria Boulevard North and Grand Central Parkway.
P.S. 41 Principal Kelly Shannon is calling on the city to put a Slow Zone on Sixth Avenue.
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