The person was near The Benson apartment building at 143 34th St., when the van slammed into the entryway of the building about 8:45 a.m., according to witnesses and an FDNY spokesman.
The pedestrian was taken to Bellevue Hospital in serious but stable condition, the FDNY said.
The van's driver suffered minor injuries, but refused medical attention at the scene, fire said. No one else was in the van when it crashed.
Residents in the apartment building were temporarily barred from using the front door until the van was removed.