Emergency responders arrived on scene at 625 Sutter Ave., between Pennsylvania and Sheffield avenues, and found the man unconscious at 9:10 a.m., a fire department spokesman said.
The Buildings Department was called to check on the loose facade early Friday morning, which was in danger of collapsing, a department spokeswoman said.
The building's owner was issued a violation for failing to maintain the building, and workers removed the loose facade, the spokeswoman said.
According to witnesses at the scene, the man was standing on a ladder working on the facade when it broke and fell into the ladder, causing the fall.
Witnesses said the incident did not look serious, but the FDNY spokesman said emergency responders rushed the man to SUNY Downstate Medical Center with major trauma. His condition was not known.