Residents have joined the Chelsea Democratic club to vote against the mayoral candidate.
Advocates said getting affordable housing in exchange for the expansion is not worth it.
The commission unanimously voted to approve the "refined and improved proposal."
The controversial Chelsea Market expansion plan will come before Community Board 4 in April.
Most polled were against a hotel and new office space included in the Chelse Market expansion plan.
The poll by supporters says 62 percent of residents are in favor, but opponents rejected those numbers.
Despite a change in design to accommodate their demands, opponents still say the expansion isn't needed.
A proposal to raise the roof of Chelsea Market is continuing to incite activists in the neighborhood.
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