The street is home to the three most collision-prone intersections in the neighborhood.
Cars will still be allowed on the East Drive during weekday rush hour, the city announced Thursday.
The city hopes to reduce crashes at the busy Prospect-Lefferts Gardens intersection.
The DOT wants to reduce each avenue from four to two lanes of traffic and add bike lanes.
The Bennett Avenue entrance to the 190th Street A train station received new safety measures.
Brooklyn Community Board 8 asked the Department of Transportation to beef up their plan.
The improvements are the first phase of redesign plans for the roadway, nicknamed "Boulevard of Death."
Transportation advocates have pushed for safety upgrades on 21st Street for the last few years.
Raymond Ramos hit the victim early Monday at the corner of Nostrand Ave. and St. Johns Pl., police said.
Councilwoman Karen Koslowitz set aside funds for a study to determine how to make the street safer.
The DOT wants to increase pedestrian and cyclist access to the High Bridge, which will reopen in July.
The event, scheduled for March 7, will begin in Forest Hills.
The area around Hillside and Jamaica avenues is among the most crash-prone sections of Queens.
The city plans to bring more speed limit signs and lights timed for pedestrians to the priority areas.
Parents at WHEELS Elementary in Fort George said the school needs more traffic-safety measures.
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