The owner said she plans to take a break and wants to take a road trip with her dog.
The 43-year-old music, electronics and computer mega-store will shut down for renovations Thursday.
More than a dozen spots in Chelsea closed over the past year. Many have yet to be replaced.
The employees at Very Good Toys East, located at 1020 Third Ave., are moving to an UWS location.
The Madison Avenue Business Improvement District said 14 stores have already opened in 2013.
An outpost of the coffee and pastry chain has replaced a defunct photo shop.
The family that runs Mr. Coco's, Mr. Piña, and Mr. Kiwi's to open new store: Mr. Melon.
The peep show and porn emporium near Madison Square Garden closed at the end of March.
Manganaro's, the family-owned, 119-year-old Italian store is calling it quits.
Sugar & Plumm Purveyors of Yumm say they'll open in their Amsterdam Avenue store in the spring.
Several restaurants, along with an green furniture store, have opened in Chelsea and Hell's Kitchen.
Dealers at the once-thriving antiques center in Chelsea have been told that the garage will close at the end of August, reports say.
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