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The design of the townhouse at 280 Convent Ave. does not fit in the historic district, opponents say.
A spokesman for St. Luke's Hospital, however, said the hospital "has no plans to cease operations."
The former P.S. 186, which has been closed for nearly 40 years, would also have 81 units of housing.
Columbia claims to have exceeded minority hiring and spending goals, but critics are skeptical.
The board says Columbia is not living up to goals it agreed to during negotiations for its expansion.
The hospital closed the pediatric inpatient unit at 114th Street and Amsterdam after Hurricane Sandy.
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