The asking price is $8.495 million for the swanky penthouse, located at at 288 West St.
The couple bought the 4,000-square-foot apartment — boasting a 45-foot-wide living room and Hudson River views — for $6.995 million in 2008, according to the site.
Connelly was one of the celebrities who vocally campaigned against the Spring Street Sanitation Garage in 2010, alongside John Slattery of "Mad Men" and James Gandolfini of "The Sopranos."
Appeals from high-profile residents ultimately failed, and the city intends to go ahead with the project, located at the corner of Spring and West streets — a short stroll from Connelly's penthouse. The Spring Street project has been controversial and mature trees have already been cleared to make way for it.
The full-floor loft has a library, glass-enclosed sunroom and 1,380 square feet of private outdoor roof space, according to the listing with Douglas Elliman. It's part of a 14 unit co-op, built in 1890 and converted in 1984.