The city is seeking proposals for the first publicly funded development at the former Sea View Hospital.
The New York City Economic Development Corporation released a request for expressions of interest (RFEI) on Wednesday to get proposals for the planned mixed-used development, Sea View Healthy Community, that will take over about 80 acres of land.
Officials want the site to become a neighborhood with shops, medical facilities, community spaces and affordable housing focused on residents' health.
"This extraordinary project will improve the quality of life for thousands of Staten Islanders and keep New York City as a national leader in pioneering approaches to public health," EDC president Maria Torres-Springer said in a statement earlier this year.
Plans call for new residential buildings for seniors and people with disabilities, hiking and bike trails, plazas and medical office space, the EDC said.
The EDC said in its RFEI the redevelopment should "promote exercise, access to nature, social engagement and good nutrition for its residents and visitors" and have health-focused programming.
The Brielle Avenue hospital opened in 1913 to treat tuberculosis patients and was the site of the first clinical trials for the hydrazides treatment that eventually led to a cure for the disease, according to the EDC.
After tuberculosis was cured, the hospital gradually started to close in the late 1950s and the 40 buildings were landmarked in 1985.
Less than half of the buildings are currently used and officials, including Borough President James Oddo, have called for their redevelopment for years.
The deadline to submit ideas for the RFEI is March 24.