From Monday through Thursday until February, the bridge will be closed to drivers from 9 p.m. until 5 a.m., and closed from Friday at midnight to 8 a.m. Saturday.
The bridge will not close overnights on Saturday and Sunday or on holiday weekends.
Drivers will be diverted to the Goethals Bridge during the closures.
The disruption is part of the Port Authority's $1.29 billion project to raise the roadway of the bridge to allow larger container ships to pass underneath, the Port Authority said. Crews will also widen the lanes and shoulders of the bridge and build a 12-foot bicycle and pedestrian path.
The raising of the roadways is expected to be finished in 2017, and people can watch the work on a 24-hour webcam set up by the Port Authority in September.