A man approached the worker in the historic Cable Building at 611 Broadway — which houses a large Crate and Barrel store and offices — about 1 p.m., cops said.
The man argued with the 29-year-old worker, whose job was to handle deliveries, and then the man punched the worker in the face, causing pain and swelling, according to police.
The attacker fled the scene but returned soon after to retrieve a messenger bag he had left behind and struck the worker again, cops said.
Isaiah Almenas, 20, was arrested and charged with misdemeanor counts of assault and attempted assault, plus a violation for harassment, NYPD and court records show.
Almenas, whose lawyer did not immediately respond to an inquiry, appeared in court Friday and was released without bail. He's due back in court Dec. 2.
A manager at Crate and Barrel said she was unable to provide any information.
Other notable crimes in this week's NYPD blotter for the 6th Precinct include:
► A motorcyclist riding on West Houston Street near Pier 40 was arrested for drunk driving early Saturday morning after he was stopped at a police checkpoint, police said.
Officers stopped the man on a black 2011 Laro motorcycle about 1 a.m. Saturday and smelled alcohol and marijuana on his breath, according to the police report.
"I have one drink — martini…Smoke weed earlier," the man with a flushed face and bloodshot eyes said, according to police.
Roman Zaydman, 47, was arrested after he refused a field sobriety test, police said. He was later found to have a blood alcohol content of 0.112 percent, exceeding the legal limit of 0.08 percent, police said.
Zaydman was hit with misdemeanor counts of operating a motor vehicle while intoxicated and while impaired by alcohol and drugs, court records show. His lawyer did not immediately respond to an inquiry.
► A woman walking past NYU's law school last Thursday morning had a bag she was carrying ripped from her hand and her backpack nearly snatched, police said.
The woman, 32, was walking on Washington Square South near MacDougal Street about 9 a.m. when a woman approached her and grabbed the plastic bag in her hand, cops said. When the plastic bag ripped, the would-be thief tried to grab the woman's backpack, but she failed to make off with anything, police said.
Patricia Leclerc, 52, was arrested several blocks away on Sixth Avenue near West 10th Street when the victim and police spotted her, cops said.
Leclerc, who appeared in court Friday, was charged with a misdemeanor count of attempted grand larceny and and was released without bail, NYPD and court records show. Her lawyer did not immediately respond to an inquiry.
Leclerc is due back in court Oct. 29.
It was not immediately known if the victim was an NYU student and the incident does not appear in campus crime reports. NYU did not immediately respond to an inquiry about the attempted theft.