Crews for the prison-based TV series were set up along 30th Avenue and 36th Street on Wednesday.
The Emmy-nominated show has been filming flashback scenes across New York.
Netflix's hit prison series will shoot a scene from its third season on Riverside Drive.
The explosion will take place between noon and 3 p.m. at the Great Kills Swim Club.
Washington Heights will be the backdrop for a scene in "A Walk Among the Tombstones."
Lucy Liu and Jonny Lee Miller were filming their hit CBS show "Elementary" in Brooklyn on Monday.
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