Sergio Bosse, 69, was found dead about midnight tied up in his bed inside his Albany Avenue apartment, near Lefferts Avenue, with a stab wound in the back of his head, sources said.
His apartment, which was upstairs from his bodega, showed no signs of forced entry and his Mercedes-Benz was missing, sources said.
Police released footage Thursday of a female associate of Bosse's inside a liquor store some time before the shopkeep's murder, the NYPD said.
Investigators said they want to question the woman, but did not describe her as a suspect of the murder.
An NYPD spokesman did not know the nature of their relationship.
Investigators initially said that Bosse had been shot in the back of the head, but the city's medical examiner clarified that he had been stabbed instead, the NYPD said.
Bosse said he was a kind community member and were shocked to learn of his death, according to Marcia Williams, who ran a restaraunt in his building.
"He was a really good man. Any issues, he would work with you. I would never imagine something like this could happen to him," Williams said.
Anyone with information is asked to call Crime Stoppers at (800) 577-TIPS (8477).